FDA-Approved Botulinum Toxins
Botulinum toxin is a highly purified protein from a naturally occurring bacterium that binds specifically to nerves to temporarily inactivate them.
Through the decades, neurotoxins have been used for both medical indications (ranging from headache to overactive bladder) and cosmetic indications (relaxing of glabellar wrinkles and crow’s feet).
There are currently three botulinum toxins approved in the United States as wrinkle relaxants:
1. Botox (onabotulinumtoxinA; Allergan)
2. Dysport (abobotulinumtoxinA; Galderma)
3. Xeomin (incobotulinumtoxinA; Merz Pharmaceuticals)
“All three products are approved for glabellar lines,” Joel Schlessinger, M.D., chief executive officer of Advanced Skin Research Center in Omaha, Neb., tells The Aesthetic Channel. “The only product, though, that has a second indication in the cosmetic arena at present is Botox, which is also approved for crow’s feet (lateral canthal lines).”
Dr. Schlessinger says all three injectables have also been used off-label as a wrinkle relaxer for the chin, forehead, bunny lines (lines around the nose), neck and chest.